abstract n-(2-bromopropionyl)-o-benzyl-l-serine (bpbs) was prepared using 2-bromopropionic acid
\nand n-boc-o-bzl-l-serine as the starting reagents. bpbs underwent the intra-molecular ring-closing reac-
\ntion in dmf\/et
\n3
\nn solvent at 80 \u2103for 9 h forming a mixture of two non-enantiomers, i.e. (3s,6s)-benzyl-
\noxymethyl-6-methyl-morpholine-2,5-dione [(3s,6s)-bmmd] and (3s,6r)-bmmd with a yield of 70%. two
\noptically pure enantiomers of bmmd, i.e. (3s,6s)-bmmd and (3s,6r)-bmmd were obtained via 4 opera-
\ntion circles of \u201csolution-partial recrystallization\u201d by means of a differential recrystallization method using
\nethyl acetate as a solvent. the single crystals of the two isomers of bmmd were grown from ethyl acetate at
\nroom temperature. the fine molecular structures of the two isomers were determined by x-ray diffraction
\nanalysis of the single crystals.
\nkeywords (3s,6s)-benzyloxymethyl-6-methyl-morpholine-2,5-dione; (3s,6r)-benzyloxymethyl-6-methyl-
\nmorpholine-2,5-dione; resolution; optical isomer; crystal structure <\/p>\n","protected":false},"excerpt":{"rendered":"
abstract n-(2-bromopropionyl)-o-benzyl-l-serine (bpbs) was prepared using 2-bromopropionic acid and n-boc-o-bzl-l-serine as the starting reagents. bpbs underwen …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.zuheliao.com\/index.php\/wp-json\/wp\/v2\/posts\/112"}],"collection":[{"href":"https:\/\/www.zuheliao.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.zuheliao.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.zuheliao.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.zuheliao.com\/index.php\/wp-json\/wp\/v2\/comments?post=112"}],"version-history":[{"count":1,"href":"https:\/\/www.zuheliao.com\/index.php\/wp-json\/wp\/v2\/posts\/112\/revisions"}],"predecessor-version":[{"id":113,"href":"https:\/\/www.zuheliao.com\/index.php\/wp-json\/wp\/v2\/posts\/112\/revisions\/113"}],"wp:attachment":[{"href":"https:\/\/www.zuheliao.com\/index.php\/wp-json\/wp\/v2\/media?parent=112"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.zuheliao.com\/index.php\/wp-json\/wp\/v2\/categories?post=112"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.zuheliao.com\/index.php\/wp-json\/wp\/v2\/tags?post=112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}